Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis
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منابع مشابه
Endoplasmic Reticulum Ca2+ Increases Enhance Mutant Glucocerebrosidase Proteostasis
Altering intracellular calcium levels is known to partially restore mutant enzyme homeostasis in several lysosomal storage diseases, but why? We hypothesized that endoplasmic reticulum (ER) calcium increases enhance the folding, trafficking and function of these mutant misfolding- and degradation-prone lysosomal enzymes by increasing chaperone function. Here we report that increasing ER calcium...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2010
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.368